rheumatology

ObjectiveRheumatoid arthritis (RA) is a chronic inflammatory joint disease and the leading cause of joint-related limb disability. Traditional Chinese Medicine (TCM) offers certain advantages in RA treatment, and Tripterygium preparations are widely used due to their significant clinical efficacy. This study aimed to investigate the mechanism of action of Tripterygium Glycosides Tablets (TG) in t…

Higher ambient PM2.5 exposure was associated with increased rheumatoid arthritis disease activity and a greater likelihood of flares in a four-year South Korean cohort of 1,070 patients. The association appeared stronger with sustained exposure over approximately two weeks or longer, while women and nonsmokers showed more pronounced links between PM2.5 and DAS28-CRP.

Rheumatoid arthritis (RA) is a systemic autoimmune disease marked by chronic inflammation and destruction of joints and surrounding soft tissues. The pathogenesis of RA is heavily driven by two intertwined and mutually regulatory processes: metabolic reprogramming and epigenetic remodeling. Recent advances reveal a crucial crosstalk wherein metabolic intermediates derived from immune cells act as…

IntroductionRheumatoid arthritis (RA) is a chronic inflammatory disease characterized by aberrant proliferation and activation of fibroblast‐like synoviocytes (FLSs), leading to production of inflammatory mediators. Although interferon regulatory factor 1 (IRF1) is known to participate in immune regulation, its specific role and upstream activation mechanism in RA‐FLSs remain elusive.MethodsIRF1 …

Rheumatoid arthritis is a long-term autoimmune disease in which the immune system mistakenly attacks healthy joints. This causes pain, swelling, stiffness, and gradual damage that can make everyday activities difficult. Although modern medicines help many people, some patients do not respond well or develop unwanted side effects, creating a need for better treatments. A new […] The post Natural P…

A plant-derived compound reduced swelling, inflammation, and joint damage in rats with rheumatoid arthritis. It also helped rebalance immune activity and improve the way certain fats were processed in the body. Researchers say the findings could lead to a new approach for treating the disease.

BackgroundRheumatoid arthritis (RA) is a systemic autoimmune disorder in which persistent synovitis drives progressive joint damage, often leading to functional limitation and a reduced quality of life. Caulophyllum robustum Maxim. (C. robustum) has long been used in traditional medicine to manage RA. Although increasing experimental evidence has demonstrated its therapeutic potential, relevant s…

Researchers at Hospital for Special Surgery (HSS) have identified a specialized population of immune cells that play a central role in driving abnormal tissue growth in rheumatoid arthritis (RA), offering new insight into disease progression and potential treatment strategies.

For the 18 million people living with rheumatoid arthritis, disease management currently means a lifetime of injections-a reality that new research from Tsinghua University may soon begin to change.

A Phase 1-2 rare rheumatology program achieved all startup milestones ahead of schedule, enrolled eight healthy volunteer cohorts back-to-back on time, and navigated a fundamentally different enrollment landscape when transitioning to patients. The team managed this while adapting to frequent strategy changes and maintaining close sponsor governance across multiple geographies.

For many people, rheumatoid arthritis seems to appear suddenly. One day they begin experiencing painful, swollen joints, overwhelming fatigue, and stiffness that makes everyday activities difficult. But scientists now know that the disease often starts developing long before the first diagnosis is made. New research from King’s College London suggests that treating people before rheumatoid […] Th…

Doctors have traditionally treated rheumatoid arthritis only after the disease becomes obvious. By the time most patients receive a diagnosis, joint damage may already be underway. A new study suggests that this approach could eventually change. Researchers from King’s College London have found that early treatment with a biologic drug can delay rheumatoid arthritis for […] The post This Drug Del…

Systemic sclerosis is a rare connective tissue disorder characterised by autoimmune features with vascular manifestations, causing fibrosis of the skin and internal organs.

A new study suggests that lingering rheumatoid arthritis symptoms are not always caused by ongoing inflammation. For people with rheumatoid arthritis, lingering pain and fatigue are often assumed to be signs that inflammation remains active. But new research suggests the real culprit may sometimes lie elsewhere. Researchers at Semmelweis University report that sleep disorders, depression, [...]

The management of psoriatic arthritis is increasingly focused on the early identification of clinical, immunological, and tissue-based phenotypes predictive of therapeutic response.

The European Alliance of Associations for Rheumatology - held its 2026 annual Congress in London, where gout was high on the agenda.

When Monique Hinchcliff, MD, MS, associate professor of medicine (rheumatology, allergy & immunology) and director of the Yale Scleroderma Program, first came to Yale, the only way to care for patients with severe, treatment-resistant Raynaud phenomenon--whose fingers were turning black--was to send them to the emergency department for hospitalization and treatment.

A promising new study suggests rheumatoid arthritis may not be as inevitable as once thought for people at high risk. Researchers found that just one year of treatment with the immune-targeting drug abatacept delayed the onset of rheumatoid arthritis by up to four years, with benefits lasting long after treatment ended.

For many people living with rheumatoid arthritis, modern medicines have changed their lives. Treatments that target inflammation can reduce joint damage, ease pain, and help patients stay active for longer. Yet there remains a group of patients who continue to suffer from pain, tiredness, and poor quality of life even after receiving the best available […] The post Why some arthritis patients sti…