rheumatology

ObjectiveThis systematic review and meta-analysis synthesize preclinical evidence to evaluate the therapeutic efficacy of sinomenine in rodent models of rheumatoid arthritis, and integrate current understanding of its potential mechanisms. This study aims to provide preclinical evidence and mechanistic insights to guide the clinical development of sinomenine for rheumatoid arthritis.MethodsThroug…

BackgroundRheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and joint damage. Despite available treatments, many patients fail to achieve adequate disease control, prompting interest in complementary approaches. In traditional Chinese medicine, multi-herbal formulations such as Formulation C (Qushi-Juanbi Granules) are used clinically to treat RA. Among its …

BackgroundPatients with rheumatoid arthritis (RA) and concomitant fibromyalgia (FM) frequently experience severe, refractory pain, elevated disease activity scores, and substantial psychological distress. Conventional treatments frequently fail to adequately address this complex pain syndrome, and evidence-based traditional Chinese medicine (TCM) interventions for this specific comorbidity remain…

Scar-driven changes in joint tissue may underlie treatment resistance in rheumatoid arthritis, opening the door to new targeted therapies. Rheumatoid arthritis (RA) affects millions worldwide, causing persistent joint pain, swelling, and stiffness when the immune system mistakenly attacks the tissue lining the joints. Over the past two decades, an expanding toolkit of anti-inflammatory and immune…

BackgroundThere is currently scarce data on the real-world effectiveness and safety of upadacitinib in patients with axial spondyloarthritis (axSpA). This study evaluated clinical outcomes and drug retention rate (DRR) at 6, 12, and 24 months in patients initiating upadacitinib for axSpA.MethodsThis prospective, observational study enrolled consecutive patients with radiographic axSpA (r-axSpA) o…

Researchers have uncovered a previously unobserved presence of the GLP-1 hormone in the joints of arthritis patients. Arthritis is not a single disease but a broad category of joint disorders that includes autoimmune conditions like rheumatoid arthritis and psoriatic arthritis, as well as degenerative diseases such as osteoarthritis. Despite their differences, many forms share common [...]

A new study published in Engineering reveals that obakulactone (OL), a natural tetracyclic triterpenoid isolated from Phellodendri cortex, exerts a therapeutic effect on rheumatoid arthritis (RA) by promoting the degradation of acyl coenzyme A thioesterase 1 (ACOT1) via the ubiquitin‒proteasome pathway and restoring the homeostasis of unsaturated fatty acids.

A study published in Rheumatology & Autoimmunity challenges the assumption that achieving clinical remission in rheumatoid arthritis is sufficient, showing that patient-reported outcomes vary significantly by drug class even when disease activity is comparable.

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that primarily affects the joints and can cause severe deformities, progressive destruction of joint structures, and significant functional impact. Although several mechanisms are known, the etiology is multifactorial and three times more women than men are affected. In addition to the joints, the disease can affect other syst…

Nature Communications, Published online: 20 April 2026; doi:10.1038/s41467-026-72038-y The treatment and diagnosis of rheumatoid arthritis (RA) remain challenging. Here, the authors use a collagen-hybridizing peptide specific for damaged collagen, allowing both therapeutic targeting and imaging of inflamed joints in a mouse model of RA.

A long-term clinical study suggests that intervening before rheumatoid arthritis fully develops may significantly alter its trajectory. Treating people before rheumatoid arthritis (RA) fully develops may buy them something medicine rarely can: time. A new long-term study suggests that in people at high risk, early treatment with abatacept can push back the start of the [...]

This research will evaluate whether Surf Therapeutic’s neuromodulation device can be used to activate a known anti-inflammatory pathway to relieve the symptoms of rheumatoid arthritis.

Clinical trial participants help move research forward while gaining access to the latest potential treatments. Rheumatoid arthritis (RA) is a chronic inflammatory disorder that affects a person’s joints, most frequently those in the hands and feet. It can also impact various other systems of the body. RA causes the immune system to attack the body’s tissue, including joints. Symptoms include pai…

The small implant helps relieve pain and joint swelling in rheumatoid arthritis and is being investigated for other autoimmune diseases

Osteoarthritis is a common disorder that typically affects older people. It occurs when the cartilage in joints break down, causing pain and stiffness that worsens over time. “There is no […] Van Andel Institute - Van Andel Institute transforms human health through groundbreaking biomedical research and cutting-edge science education.

Asymmetrical inflamed joints Hope for those suffering from peripheral spondyloarthritis By Els Verweire This article originally appeared in Dutch in EOS Magazine. Read more at eoswetenschap.eu. Patients with peripheral spondyloarthritis face a lifetime of medication, as this rheumatic condition rarely or never spontaneously disappears. Researchers from the VIB-UGent Center for Inflammation Resear…

Annals of Reviews and Research - Juniper Publishers Abstract Hashimoto’s thyroiditis, or chronic lymphocytic thyroiditis, an autoimmune disorder targeting the thyroid gland, presents a global health concern. This review compiles current knowledge, advancements in research findings, and emerging trends related to this condition’s etiopathogenesis, diagnosis, management, and complications. The…

By profiling the inflammatory cells types in joint tissue biopsy samples, scientists have characterized six subtypes of rheumatoid arthritis, an approach that could help physicians tailor more effective treatment strategies for patients based on disease type, according to findings published in Nature. The post Defining Rheumatoid Arthritis Subtypes May Improve Treatments appeared first on News Ce…

Arthritis & Bone Research - Juniper Publishers Abstract In the treatment of patients with rheumatoid arthritis with anti-tumour necrosis factor therapy, it is not uncommon for some patients to be unresponsive or relapse with treatment. We report the successful usage of combination biologic therapy with etanercept and tocilizumab in two patients with moderately severe rheumatoid arthritis who…