Frontiers in Human Neuroscience | Brain Health and Clinical Neuroscience section | New and Recent Articles

ObjectiveLong COVID, or post-COVID-19 syndrome, is characterized by persistent symptoms following SARS-CoV-2 infection, including cognitive impairments such as “brain fog” that adversely affect quality of life. The aim of this study was to evaluate the impact of long COVID on working memory using a single, rapid, anonymous online survey and visual working memory quiz.MethodsWe analyzed working me…

Parkinson’s disease (PD) is a progressive neurological disorder characterized by motor symptoms, with treatment responses varying widely across patients. To address the growing need for individualized treatment strategies, this paper introduces a practical framework for constructing optimal individualized treatment strategies using weighted support vector machines (SVMs). We construct an optimal …

Background A 27-year-old male with perinatal hypoxia presented with global developmental delay, progressive hearing loss, ataxia, dysarthria, and intellectual disability. Whole-exome sequencing revealed compound heterozygous ACAD9 variants: c.456del (p.Ile153Serfs*46) and c.869G > A (p.Gly290Glu). Brain MRI showed bilateral cerebellar atrophy and a prominent cisterna magna. OCT confirmed optic at…

The SCN8A gene encodes the voltage-gated sodium channel NaV1.6, which is essential for neuronal excitability and action potential propagation. SCN8A variants are associated with a broad clinical spectrum, ranging from self-limiting syndromes to developmental and epileptic encephalopathies. Here, we identified a novel de novo heterozygous SCN8A variant (c.791 T > C/p.Val264Ala) in a 19-year-old fe…

BackgroundDementia prevalence is projected to rise most sharply in low-and middle-income countries, including Brazil. The Brazilian Black population (including individuals identified as Black and Brown) represents 56.5% of the population and is expected to comprise most older adults in the coming decades.AimsThis narrative review aims to synthesize studies on dementia, cognitive decline, and cogn…