bacterial-infections-and-vaccines

Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections in infants, young children, immunocompromised adults, and elderly individuals with comorbidities. Its high pathogenicity and associated mortality impose a substantial disease burden on public health. Vaccination represents a key strategy for preventing RSV infection. However, currently approved RSV v…

Top medical groups band together to ease confusion from Trump administration’s changing immunization advice Leading US medical groups are urging people to get updated flu and Covid-19 vaccinations this fall, banding together on Wednesday to issue shot guidelines – and highlight the science behind them – saying they hope to ease confusion caused by the Trump administration’s changing advice. Flu v…

Influenza viruses constantly shapeshift to evade recognition by the immune system. This shapeshifting occurs in critical proteins like hemagglutinin (HA), which controls how the virus attaches to human cells before entering them. Influenza viruses can evade immunity in two major ways: through the gradual accumulation of mutations that make HA harder for the immune system […]

ABSTRACT Aim To determine whether remote recruitment, electronic consent and at‐home blood collection enabled enrollment of a geographically and socioeconomically diverse infant cohort in the United States (US). Methods We describe the demographics of 256 infants included in this analysis, drawn from 264 enrolled in the Infant Vaccine Biorepository (December 2022–April 2026). Participants were re…

Streptococcus pneumoniae , a common pathogen to cause pneumonia and otitis media, is also the most important causative agent of bacterial meningitis in humans. Previous studies have shown that S. pneumoniae strains can be pilus-negative, type I pilus- and/or type II pilus-positive, and pneumococcal pili promote adhesiveness and induce inflammation in hosts. However, the role of S. pneumoniae pili…

Abstract Background Pertussis, an acute respiratory infection caused by Bordetella pertussis ( B. pertussis ), has resurged in China. Biofilm formation has recently been associated with the pathogenesis of B. pertussis . This study aims to analyze the biofilm formation capacity of circulating isolates and investigate the phenotype–genotype associations between biofilm formation and genomic charac…

OBJECTIVE Pediatric intracranial abscesses are rare, life-threatening infections requiring prompt surgery and coordinated subspecialty care. Reports during COVID-19 described nationwide surges, but national operative trends and equity data remain sparse. Therefore, this study aimed to define decade-long trends in surgical management, outcomes, and racial disparities in children in the US who unde…

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