BMC Microbiology

Abstract Background The proliferation and dissemination of carbapenem-resistant Klebsiella pneumoniae (CRKP) constitutes a critical public health concern, underscoring the urgent need for novel antimicrobial agents. In this study, we identified cladribine, a synthetic purine analogue, as a potential antimicrobial candidate against CRKP. Results Cladribine exhibited an MIC of 64 μg/mL against clin…

Abstract Background Encephalitozoon cuniculi is an obligate intracellular parasite that affects birds and mammals, including humans, and belongs to the phylum Microsporidia. The innate immune system serves as the first line of defense against infection, but it only partially clears the parasite. Microsporidia are known to modulate the effector functions of phagocytes. They can survive and multipl…

The emergence and escalation of antibiotic resistance in community and hospital settings remain a major public health concern worldwide. The co-occurrence of fluoroquinolone resistance in extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E), which are responsible for life-threatening infectious diseases, poses a critical threat, leading to increase therapeutic costs, prolonged hospit…

A growing body of literature connects the gut mycobiota to several diseases, including HIV infection. In contrast to bacteria, fungi represent a smaller fraction of the gut microbiota and pose several technical challenges, including low biomass, environmental contamination and primer-associated biases. Characterizing the gut mycobiota in HIV infection is still at an early stage. We characterized …

Carbapenem-resistant Enterobacterales are increasingly reported worldwide, posing significant treatment challenges, especially in vulnerable pediatric populations. This study describes the molecular epidemiology and antimicrobial susceptibility of carbapenem-resistant Enterobacterales isolated from infants under one year of age in Niger. This prospective case series reports on 14 children < 1 yea…

Pseudomonas aeruginosa is an opportunistic pathogen and a major cause of healthcare-associated infections globally. Understanding the distribution and interaction of its virulence factors in under-investigated regions is crucial for surveillance and targeted interventions. This study aimed to comprehensively characterize the phenotypic and genotypic virulence profiles of P. aeruginosa clinical is…