STROBE

The purpose of the NSF Graduate Research Fellowship Program (GRFP) is to help ensure the quality, vitality, and strength of the scientific and engineering workforce of the United States. Since 1952, the program recognizes and supports outstanding graduate students who are pursuing full-time research-based master's and doctoral degrees in science, technology, engineering, and mathematics (STEM) .…

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Microscopy and crystallography have long served as two foundational pillars of experimental science. Microscopy relies on lenses to visualize local structures, whereas crystallography determines the global atomic arrangement of crystals through diffraction. Over the past two decades, these traditionally distinct methodologies have been unified through the rise of computational microscopy, particu…

The convolutional network is the preferred option for handling large input sizes and is commonly used in neural networks for most applications. In this experiment we demonstrate the performance of a modified convolutional neural networks (CNN) using an exponent based weight. The Exponential Convolutional Neural Network (ECNN) was tested on bacteria classification, with different model . . .

High fidelity soft X-ray imaging using both tabletop and facility-scale light sources is very powerful, enabling static and dynamic imaging with ~10 nm spatial resolution. However, it can suffer from several challenges. First, phase-matched soft x-ray high harmonic generation (SXR HHG) produces a bright supercontinuum that is spatially and temporally coherent. However, reconstructing objects from…

In many areas of non-invasive optical imaging, particularly in biology and materials science, the use of conventional fluorescence-based microscopy techniques is constrained by a number of factors, including the need for molecular labels and the occurrence of photobleaching. Optical scattering methods provide a powerful alternative that can overcome these limitations by detecting the inherent lig…

A new approach for high-resolution, three-dimensional elemental imaging has been demonstrated using soft X-ray ptychographic tomography. This technique leverages both optical density and phase contrast reconstructions to identify elements from a single-energy tilt series, reducing acquisition time by more than half compared to traditional multi-energy tomography. The method was validated on nicke…

Semiconductor nanowires offer unique opportunities for next-generation electronic and photonic devices due to their high surface-to-volume ratio, ability to suppress dislocations, accommodate large lattice mismatches, and support both axial and radial heterostructure growth. In particular, the non-polar planes of GaN nanowires provide a promising platform for high-performance optoelectronics by m…

Laser driven x-ray sources are capable of achieving nanometer length scale imaging while simultaneously durations on the order of nanoseconds, enabling microscopy at the fastest timescales and the smallest length scales. Through the use of mid-infrared lasers, the generated light can extend into the soft x-ray regime, where there are exciting applications in biological . . .

Abstract: While electron microscopy enables imaging of individual atoms, the sample thickness is typically limited to a few hundred nanometers. Although super-resolution optical microscopy permits high-resolution visualization of subcellular structures, it requires staining of the sample. In contrast, EUV and X-ray microscopy allow imaging of entire biological cells and other thick specimens with…

Congratulations to Yueyun Chen, a graduate student in Chris Regan's group, for receiving the 2025 Castaing Award for Best Student Paper from Microscopy & Microanalysis!