biophysics

Tim Sluckin·...·University of Southampton
3d ago

Theoretical physicists are caricatured in the popular imagination as only involved in abstruse and difficult-to-imagine topics. But some of these theoretical physicists are involved in something closer…

Conventional image analysis loses vital structural information from orientation signatures within Fourier phase, easily disrupted by cellular rotation. Quantum Phase Bicoherence (QPBC) spectroscopy now overcomes this limitation, consistently resolving angular order and discriminating biological phenotypes across diverse imaging datasets. This new framework includes a built-in self-check via inher…

Understanding the three-dimensional structure and mechanical response of biomolecules is key to uncovering their molecular mechanisms, particularly in contexts where force plays a regulatory role. Structural methods such as X-ray crystallography, Cryo-electron microscopy, and Nuclear Magnetic Resonance (NMR) spectroscopy provide high-resolution conformational data, while single-molecule force spe…

In El legado de Humberto Maturana y Francisco Varela: Desarrollos, desafíos y aplicaciones de la teoría autopoiética en el siglo XXI. Santiago de Chile: Ediciones Colegas. pp. 47-69. 2026This chapter examines whether teleological vocabulary can retain scientific legitimacy in biology without positing intentional purposes or sui generis properties. From a naturalistic standpoint, I defend a modest…

[Purpose] The qi-transformation (气化) theory in Chinese medicine describes the rhythmic adjustment of human physiological functions across seasons, but its driving source has long remained unidentified. Modern chronobiology has confirmed the molecular mechanism of the human biological clock but has not "why rhythms necessarily exist." Starting from the planetary dynamics framework established in t…

Nature Communications, Published online: 17 August 2026; doi:10.1038/s41467-026-76703-0 Understanding molecular orientation is essential for unveiling biological structure and function. Here the authors develop a robust, high-fidelity framework (eGRL) for reconstructing complete 3D density and 3D orientation distributions of fluorescent molecules with polarized fluorescence microscopy.

Nonequilibrium Medicine; NEM; nonequilibrium thermodynamics; nonequilibrium biology; medical systems; energy flow; metabolic flux; dissipati Nonequilibrium Medicine; NEM; nonequilibrium thermodynamics; nonequilibrium biology; medical systems; energy flow

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