Cryo-EM structures of heteromeric Kir4.1/5.1 channel suggest mechanisms of inward rectification and channel blockage

Nature Communications, Published online: 06 June 2026; doi:10.1038/s41467-026-74087-9 Kir4.1/5.1 channels are vital for brain and kidney function. Here the authors combine structural, electrophysiological, and computational studies to reveal an inner-ring pore blockage mechanism by polyamines and inhibitors, providing the structural basis for inward rectification.