Life in the Lab

Traditional vs Integrated Harvest and Clarification Thermo Scientific Harvest RC Centrate Clarifier Purpose-built for centrate clarification, this single-use, single-stage solution uses anion exchange chromatographic technology to remove soluble and insoluble impurities with high efficiency. It enables process compression, high product recovery, and consistent performance across scales. Together,…

How can we isolate exosomes rapidly, reproducibility, and specifically-without compromising data quality downstream? Exosomes are nanoscale extracellular vesicles (30–150 nm) that play a critical role in cell-to-cell communication, disease progression, and biomarker discovery. Because they carry proteins, RNA, and lipids reflective of their cell of origin, exosomes have become essential tools in …

What is Real-Time Quantitative PCR and how does a lysate-based system expedite gene expression? Real-Time Quantitative PCR terminology Real-Time reverse transcription polymerase chain reaction, often abbreviated RT-qPCR, is a technique used to detect and quantify RNA. It is particularly useful for measuring gene expression levels. But how did this nomenclature come to pass? Let’s start The post E…

DNA size selection plays a central role in determining the quality, efficiency, and reproducibility of next-generation sequencing (NGS) libraries. While often discussed as a discrete step, size selection is best understood as part of a continuum that begins with DNA clean up and extends through deliberate shaping of fragment size distributions. Together, these processes determine The post DNA siz…

The post Reducing risk in continuous downstream bioprocessing: 3 innovations process engineers can use today appeared first on Life in the Lab .

In pharmaceutical and biotechnology research and in-vitro diagnostics (IVD) development, immunoassays play a critical role in quantifying biomarkers, monitoring pathway modulation, and evaluating compound activity. While plate-based ELISAs have long been the industry standard, modern discovery workflows increasingly require higher analytical sensitivity, faster turnaround times, improved reproduc…

Authors: Penny J. Jensen & Janaki Narahari Choosing the right cell-based assay is a critical step in designing reliable experiments, but with so many options available, it can be difficult to know where to start. If you’re wondering how to choose a cell-based assay, the answer depends on your biological question, the type of cells The post Practical Considerations for Choosing a Cell-Based Assay …

Immunopeptidome analysis enables the comprehensive identification of major histocompatibility complex (MHC)-bound peptides to better understand antigen presentation and immune recognition. By combining targeted immunoprecipitation workflows with high-resolution peptide identification by mass spectrometry, researchers can characterize thousands of MHC-associated peptides with high sensitivity and …

CRISPR genome editing has transformed how scientists study genes, model diseases, and develop new therapies. Yet one challenge remains at the forefront: genetic variation. Every individual’s genome carries millions of unique differences, and even a single variant can make or break a CRISPR experiment. At Thermo Fisher Scientific, we’re helping researchers address this challenge with The post True…

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Integrated mAb process intensification refers to the coordinated optimization of upstream and downstream manufacturing steps to increase throughput, reduce cost per gram, and improve facility utilization while maintaining product quality. Rather than optimizing unit operations independently, integrated intensification aligns bioreactor productivity, harvest capacity, purification throughput, and …

Traditional CLD vs kit-based CLD approach* Frequently Asked Questions The post Accelerating CHO cell line development: Tackling the bottlenecks with smarter tools appeared first on Life in the Lab .

Recent advancements in the field of Molecular biology have significantly influenced the evolution of recombinant antibodies, rendering them important reagents for scientific research. Recombinant antibodies are a modern alternative to traditional hybridoma-based antibodies, which are generated by fusing B cells with immortalized myeloma cells. Recombinant antibodies are engineered using genetic t…

Parkin is a critical protein in Parkinson’s disease research, widely studied for its role in mitochondrial quality control and neurodegeneration. However, because Parkin is expressed at very low endogenous levels and undergoes complex post-translational modifications, accurately detecting it remains a persistent challenge for researchers. High-quality Parkin antibodies are therefore important for…

Eligible for 1 contact hour or 0.15 continuing education credits (CECs) Next-generation sequencing (NGS) technologies transformed the HLA typing field by generating high-resolution data and resolving most allelic ambiguities without multiple reflexive tests. High-performance NGS HLA assays demand high-quality genomic DNA from biological samples such as peripheral blood. Please watch this on-deman…