Glycoprotein VI, or GPVI for short, is a surface receptor found exclusively on platelets and their precursor cells, megakaryocytes in the bone marrow. GPVI is primarily responsible for binding collagen at the site of an injured blood vessel, which triggers the activation and aggregation of platelets.
Thrombosis associated with HIF-PH inhibitor therapy has become a major concern. While elevated transferrin (Tf) levels were previously thought to be the cause, recent findings suggest that Tf may actually inhibit thrombus formation. I propose a new hypothesis based on my own theory.
ObjectiveEndovascular thrombectomy (EVT) is the standard treatment for acute ischemic stroke caused by large-vessel occlusion (AIS-LVO), but incomplete microvascular reperfusion often limits recovery. The 2026 American Heart Association/American Stroke Association guideline suggests that adjunctive intra-arterial thrombolysis (IAT) may be considered after successful EVT to target residual microth…
Scientific Reports, Published online: 28 June 2026; doi:10.1038/s41598-026-59203-5 Computational analysis of thrombosis risk in a patient with left ventricular assist device
Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy resulting either from congenital deficiency (cTTP) or acquired (immune) deficiency (iTTP) of A Disintegrin and Metalloprotease with ThromboSpondin-type 1 motif, member 13 (ADAMTS13). Deficiency of ADAMTS13 leads to disseminated platelet thrombosis and organ dysfunction. High mortality of cTTP is prevented by plasma infusion…
