Pathways Through Which Iron Deficiency Under HIF-PH Inhibitor Administration Triggers Thrombosis and How to Handle It: A New Mechanism Proposal from the Six-Factor Theory of Erythropoiesis Control

Thrombosis associated with HIF-PH inhibitor therapy has become a major concern. While elevated transferrin (Tf) levels were previously thought to be the cause, recent findings suggest that Tf may actually inhibit thrombus formation. I propose a new hypothesis based on my own theory.