internal-medicine

Introduction: Skin wound healing in cancer patients is a complex issue, influenced by both the tumor process itself and the effects of antitumor therapy. This study assessed the efficacy of various skin wound treatment regimens in mice with transplanted Lewis lung carcinoma (LLC). Materials and Methods: 72 C57BL/6 mice were divided into six groups, including control, topical application of 1% cer…

A study published in Nature Medicine looks at biological ageing and early-onset cancer risk.    Dr John Riches, Clinical Reader in Cancer … read more

ObjectiveThis study aimed to compare the psychological burden of informal caregivers of patients with earthquake-related dependency and those caring for patients with stroke-related dependency following the 6 February 2023 Türkiye–Syria earthquakes.MethodsA total of 90 informal caregivers of dependent patients were included in this comparative study: 60 caregivers of stroke patients and 30 caregi…

ObjectiveAmong evidence-based treatments for personality disorder (PD), mentalization-based treatment (MBT) represents a manualized, long-term treatment. Both MBT and non-manualized psychotherapeutic treatments (NMT) are currently applied for patients with PDs in Norway. This clinical population is characterized by varying impairment of personality functioning (PF). Few have investigated how MBT …

Although pharmacological treatments for insomnia remain widely prescribed, their long-term use is constrained by risks of tolerance, dependence, and residual daytime effects. This has prompted growing interest in non-pharmacological interventions that target insomnia’s underlying mechanisms. This narrative review examines five physical factor therapies for insomnia: auditory stimulation, photothe…

IntroductionWhile prenatal depression is recognized as a significant public health issue, its specific impacts on fetal development and subsequent infant growth in the first year of life remain insufficiently characterized in Chinese populations. This study aimed to investigate the effects of prenatal depression exposure on neonatal outcomes and early infancy developmental trajectories.Materials …

IntroductionSome patients experience increased daytime sleepiness during early dCBT‑I, which may affect function and adherence. This study aimed to investigate daytime sleepiness during dCBT‑I, explore its influencing factors, and evaluate its predictive value for treatment efficacy.MethodsA retrospective analysis was conducted on 2271 insomnia patients treated at the sleep clinic of Hangzhou Sev…

BackgroundIncreasing psychotropic prescribing has raised concerns about long-term safety and regimen complexity in mental health care. Although psychotherapy is an established treatment, its role in medication optimization and psychotropic medication reduction in real-world practice across patient subgroups remains insufficiently characterized.ObjectiveTo evaluate whether initiation of psychother…

BackgroundDespite strong evidence for cognitive behavioral therapy for insomnia (CBT-I), uptake remains constrained by poorly understood cognitive, attitudinal, and practical barriers. This study examined determinants of willingness to enroll in sleep improvement programs among adults at risk of sleep disorders—including insomnia, obstructive sleep apnea, and comorbid psychological distress—atten…

IntroductionLecanemab is a monoclonal antibody targeting amyloid-beta (Aβ) approved for treating Alzheimer’s disease (AD) with mild cognitive impairment or mild dementia. Continuous monitoring of its real-world safety profile remains essential. This study aimed to analyze lecanemab-related adverse events (AEs) using the FDA Adverse Event Reporting System (FAERS) database and a multicenter cohort,…

BackgroundChildren with solid tumors experience prolonged treatment, repeated hospital visits, and psychosocial stressors. This exploratory single-center cross-sectional study evaluated anxiety symptoms, depressive symptoms, and health-related quality of life in children with solid tumors and examined their associations with selected sociodemographic, clinical, school functioning, and social func…

Nature Communications, Published online: 22 June 2026; doi:10.1038/s41467-026-74698-2 A study in mice and humans reveals that a placental enzyme AOC1 and the molecule spermidine help time labor through regulating autophagy. Boosting spermidine prevented preterm birth, suggesting a potential therapy for human premature labor.

The event highlighted research aiming to enhance the detection of eye diseases using AI and maps of the retina, alongside emerging science addressing macular degeneration, glaucoma, myopia and more. The post USC Roski Eye Institute marks golden anniversary with forward-looking symposium appeared first on USC .

Insider indicates Ockenden inquiry has uncovered appalling behaviour including racism toward mothers The report of the inquiry into the biggest maternity scandal in NHS history will outline “horrendous” failings in the care provided to women in Nottingham, the Guardian can reveal. A catalogue of appalling behaviour over many years by staff at the city’s two hospitals – Queen’s Medical Centre and …

BackgroundBiktarvy, a second-generation integrase strand-transfer inhibitor, is approved for treating human immunodeficiency virus (HIV) in patients with no known resistance to its components. This study compared adverse events (AEs) associated with biktarvy based on data from the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database and real-world evidence fr…

BackgroundChronic Hepatitis B (CHB) is a major global health concern. This study aimed to evaluate whether myxovirus resistance 2 (MX2) and sterile alpha motif domain containing 4A (SAMD4A) mRNA levels in peripheral blood mononuclear cells (PBMCs) can predict early treatment responses to pegylated interferon-alpha (Peg-IFN-α) in hepatitis B e antigen (HBeAg)-positive CHB patients.MethodsThis pros…

BackgroundPlant-Derived Exosome-Like nanoparticles (PELNs) are vital bioactive vesicles from medicinal plants, containing protective flavonoids, polyphenols, alkaloids, terpenoids, saponins, polysaccharides, and microRNAs. These compounds play crucial roles in PELNs’ anti-inflammatory and other pharmacological effects. PELNs show promise as a treatment in animal experiments for ulcerative colitis…