vascular-biology

BackgroundAberrant VSMC proliferation, migration, and phenotypic switching drive vascular remodeling. Oxidative stress is pivotal, but effective antioxidants are limited.MethodsA catalase-loaded nanocapsule (CAT-nc) was developed for sustained ROS scavenging in Ang II-induced VSMCs.ResultsCAT-nc reduced ROS, inhibited proliferation/migration, restored contractile phenotype via PTEN reactivation a…

Researchers have developed a new platform that can replicate different types of blood vessel structures. Blood vessels are less like straight pipes and more like a crowded city road map, with turns, forks, and sudden choke points that can change how traffic moves. For a long time, many lab built vessel models skipped that complexity [...]

UVA Author: Gael Genet Citation: Genet G, Genet N, Paila U, Cain SR, Cwiek A, Chavkin NW, Serbulea V, Figueras A, Cerdà P, McDonnell SP, Sankaranarayanan D, Huba M, Nelson EA, Riera-Mestre A, Hirschi KK. Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. Circulation. 2024 Mar 19;149(12):944-962. doi: 10.1161/CIRCULATIONAHA.122.0629…

UVA Author: Karen Hirschi Citation: Marziano C, Genet G, Hirschi KK. Vascular endothelial cell specification in health and disease. Angiogenesis. 2021;24(2):213-236. doi:10.1007/s10456-021-09785-7 DOI: https://link.springer.com/article/10.1007/s10456-021-09785-7 Pub-Med Number: 33844116 There are two vascular networks in mammals that coordinately function as the main supply and drainage systems o…

Alghanem AF, Abello J , Maurer JM, Kumar A, Ta CM, Gunasekar SK, Fatima U, Kang C, Xie L, Adeola O, Riker M, Elliot-Hudson M, Minerath RA, Grueter CE, Mullins RF, Stratman AN , and Sah R

Stratman AN , Burns MC, Farrelly OM, Davis AE, Li W, Pham VN, Castranova D, Yano JJ, Goddard LM, Nguyen O, Galanternik MV, Bolan TJ, Kahn ML, Mukouyama Y, and Weinstein BM