The discovery of SBS111 in colorectal cancer offers new perspectives on mutational processes and DNA repair, emphasizing its significance in tumor biology.
Nature Communications, Published online: 04 July 2026; doi:10.1038/s41467-026-75127-0 Mucinous colorectal cancers form cell clusters whose apicobasal polarity influences tissue interaction and disease progression. Here, the authors show that collagen engagement activates a HER2/HER3/SorLA-β1-integrin signaling axis that promotes integrin recycling, polarity reversion, and tumor–stroma interaction.
Nature Communications, Published online: 11 June 2026; doi:10.1038/s41467-026-73980-7 Cancer associated fibroblasts (CAFs) are important regulators of breast cancer (BC) progression. Here the authors identify a distinct pro tumorigenic myofibroblastic CAF population that derives from bone-resident Osterix+ osteolineage cells and retains osteolineage features in the tumor microenviroment.
Nature Immunology, Published online: 19 May 2026; doi:10.1038/s41590-026-02505-7 In this Resource paper, Krummel and colleagues provide analysis of 15 commonly used syngeneic mouse tumor models and compare these to the diversity of human tumor microenvironments.
