Nature Communications, Published online: 04 July 2026; doi:10.1038/s41467-026-75127-0 Mucinous colorectal cancers form cell clusters whose apicobasal polarity influences tissue interaction and disease progression. Here, the authors show that collagen engagement activates a HER2/HER3/SorLA-β1-integrin signaling axis that promotes integrin recycling, polarity reversion, and tumor–stroma interaction.