Biederer Lab

The Biederer lab enjoyed a fun-filled day at the Yale Outdoor Education Center in East Lyme, including kayaking, tetherball, corn hole, and a potluck. It is always nice to spend time together and connect with other labs!

Excited to share that our Team Biederer just wrapped up our annual meeting – made possible with the support of the ASAP (Aligning Science Across Parkinson’s) Foundation. We discussed our progress defining the vulnerability of cortical synapses and neurons to neurodegeneration in Parkinson’s disease and aligned on new goals. Great to have new opportunities for […]

  We are thrilled to announce that Saroj was awarded a pilot from from Yale’s Alzheimer’s Disease Research Center (ADRC). This project, titled CSPα as a Therapeutic Candidate in Amyloid-β with Lewy-type Co-Pathology, will probe whether a synaptic protein can modulate copathology of aggregated synuclein and amyloid-β which frequently occur in human patients. In addition […]

Dayana was awarded a Yale/NIDA Neuroproteomics Center Pilot Research Project Grant which provides funding for sample preparation and proteomic analysis through Yale’s Neuroproteomics Center. Dayana’s project is on Mechanisms of Cortical Synapse Remodeling by the Psychoactive Compound Psilocybin, which investigates how psilocybin alters the expression of synaptic adhesion proteins such…

We are thrilled to announce that Saroj was awarded a pilot from from Yale’s Alzheimer’s Disease Research Center (ADRC). This project, titled CSPα as a Therapeutic Candidate in Amyloid-β with Lewy-type Co-Pathology, will probe whether a synaptic protein can modulate copathology of aggregated synuclein and amyloid-β which frequently occur in human patients. In addition to […]

Congratulations to Dayana on winning the Young Scientist Symposium Award at the 2025 Annual Meeting of the Sociedad Chilena de Neurociencia (SCN), held in Valdivia, Chile.  As part of this recognition, Dayana was invited to present her research on the synaptic mechanisms involved in Parkinson’s disease. We are so proud of you, Dayana!

We had fun celebrating our lab tradition of making Glühwein before the holidays. A great way of revisiting the past year in research and appreciating the good work everyone is doing. And for luring our colleagues into our seminar room with the cinnamon and clove smell. Wishing everyone the best for the holidays and the […]

We are excited that our team was awarded funding from the Aligning Science Across Parkinson’s (ASAP) initiative! We want to understand cognitive impairments in Parkinson’s disease and how aggregation of the pathological protein α-synuclein impacts cortical connectivity and function. Our team is truly multidisciplinary, with joint efforts by Mike Higley and Elena Gracheva at Yale, […]

We’re excited that Dayana is joining our group as a postdoc to study cortical aberrations in Parkinson’s disease. Her curiosity about synapse biology makes for a perfect start. Celebrating her arrival from Seoul via her native Chile in New Haven style over pizza.

Dhruba’s farewell dinner was a great time to celebrate his success! He’s off to Hyderabad to return to his native India as a group leader. We wish you all the best! Your molecular thinking added a lot of strengths to our group, and it will be great that you can advance them further in your […]

We are excited to move into the new Neuroscience Institute at 100 College Street! It is outstanding to be part of the vibrant neuroscience community coming together here in one space. We’ve always been multidisciplinary in our research, and it will be great to learn from our colleagues and new neighbors and work with each […]

Our new study reveals that human milk provides a key micronutrient to support the wiring of the infant brain. This work is published in the Proceedings of the National Academy of Sciences USA. Our starting point was a lead provided by our partners at Mead Johnson Nutrition/Reckitt who performed a detailed analysis of milk samples […]

The diversity of synapse-organizing molecules opens up tremendous cooperative potential, yet the extent to which this is utilized is incompletely understood. We now report in Nature Communications that the postsynaptic adhesion proteins LRRTM1 and SynCAM 1 act together in the prefrontal cortex to control synaptic connectivity. Our results show that the functional cooperation of synapse-organizing…

Are you interested in how bioactive dietary compounds impact brain functions? Our virtual Deep Dive workshop on September 29th will give answers, connecting neuroscientists and nutrition researchers. It will be co-hosted by the HNRCA, Boston and the American Society for Nutrition. Our first session will cover the effects of diet on infant brain development and […]

Our nutritional neuroscience research program in our additional lab site, located at the HNRCA in Boston, is moving forward. Erica is leading the effort since this fall as we grow the lab and investigate the striking effects of select bioactive dietary compounds on connectivity in the brain. Lining up the ducks like here on the […]

This is the time for our lab tradition, Glühwein for the Holidays. While some of us were off to far-flung places (Boston, South Korea, …), the rest of us enjoyed this Bavarian version of mulled wine together with truffles. A nice way to get ourselves into a holiday spirit, which is much needed these days.