NeuroImage

The human anterior olfactory nucleus (AON) is one of the earliest brain regions affected by tau and beta amyloid pathology in Alzheimer's disease, potentially serving as a conduit for the spread of aggregated proteins to downstream cortical regions. However, the architecture of the human AON remains poorly understood. Here, we applied a multimodal imaging framework combining ultra-high-field magn…

Functional magnetic resonance imaging (fMRI) is the most commonly used technique for non-invasive exploration of human cognition and neuroscience. Conventional T2*-weighted single-echo resting-state fMRI (SE-rfMRI) is limited by signal loss in regions prone to susceptibility artifacts and inseparable confounding from non-neuronal baseline (i.e., initial signal intensity S0) fluctuations. While mu…

OBJECTIVE: To characterize functional network alterations associated with aphasia and preserved language function in patients with left-hemispheric brain tumors using resting-state fMRI graph-theoretical analysis, with secondary evaluation of whether whole-brain network metrics are associated with aphasia status within the tumor cohort. MATERIALS AND METHODS: This retrospective IRB-approved study…

Functional Positron Emission Tomography (fPET) data offers novel insights into brain energy demands and molecular connectivity. Recent advances in improving temporal resolutions for this imaging technique have opened up new research possibilities. However, lower signal-to-noise ratios (SNR) inherent to short PET frames bring into question whether current realignment approaches still provide appro…

BACKGROUND: Electroencephalography (EEG) can be combined with transcranial magnetic stimulation (TMS) to perform brain-state-dependent stimulation. EEG-TMS studies have shown that corticospinal excitability, as measured via motor evoked potentials (MEPs), is associated with pre-stimulus periodic EEG features, such as sensorimotor mu-rhythm phase and power. However, the influence of aperiodic brai…

In 59 drug-resistant epilepsy patients undergoing stereo-electroencephalography, we evaluated relationships between rates of 80-250 Hz high-frequency oscillations (HFO-Rs) and standardized neuropsychological scores. We also quantified how local HFO-Rs modulate functional connectivity among brain regions showing significant HFO-R-cognitive score associations. We hypothesized that regional variatio…

Cortical beta oscillations are central to motor control. These rhythms are modulated during movement preparation and execution and are also sensitive to cognitive factors such as uncertainty and attention. However, their distinct motor and cognitive roles-roles that may inform condition-specific therapeutic strategies-remain unclear. This study aimed to characterise the respective contributions o…

Musicians' perceptual advantages are often concentrated in the auditory rather than the visual modality. However, whether the relationship between musical training and the core cognitive ability of inhibitory control exhibits auditory modality specificity remains unclear. To address this gap, the present study employed matched visual and auditory Go/No-go tasks combined with electroencephalograph…

Humans and other animals learn from feedback, by tending to repeat rewarded behavior and change behavior that receives negative feedback. Previous findings suggest that feedback does not need to be consciously perceived in order to be effective. Using continuous flash suppression, we presented participants with visible and invisible positive and negative feedback during a time estimation task whi…

Attention is a cornerstone of cognitive function, and understanding its neural mechanisms is of great significance for both cognitive science and clinical applications. A critical aspect of this endeavor involves elucidating how the brain's network architecture shifts between internally- and externally-directed states. However, the distinct organizational principles of neural networks in these st…

Dexterous hand motor behavior emerges from coordinated interactions within a distributed brain network. While task-related neural dynamics have been investigated, recent fMRI studies showed that also spontaneous - i.e. non-task related - brain connectivity can predict task-specific performance. Still, it remains unclear whether spontaneous functional connectivity reflects also the encoding of gen…

The insula is a brain region that is correlated with attention in humans. Aberrant insula function is also implicated in attentional impairments in several psychiatric disorders, such as attention deficit hyperactivity disorder (ADHD), major depressive disorder (MDD), and schizophrenia. Although the insula's role in attention has been well-studied in humans, we do not yet have an understanding of…

Magnetic resonance imaging (MRI) is a valuable clinical and research tool for patients managed using deep brain stimulation (DBS). Unfortunately, MRI under these conditions is associated with substantial risks, necessitating stringent regulations that limit its clinical and research utility. In addition, magnetic susceptibility differences between DBS hardware and surrounding tissues significantl…

These findings advance the understanding of structural and individual-level network alterations underlying MDD biotypes and provide novel insights into the neurobiological mechanisms of MDD heterogeneity.

In everyday life, our behavior is often guided by environmental cues that predict rewarding or aversive outcomes. The Pavlovian-to-Instrumental Transfer (PIT) paradigm provides a framework for examining how conditioned stimuli (CS) influence instrumental actions (R) associated with specific outcomes (O). Two distinct mechanisms have been identified: specific PIT, where a cue selectively invigorat…

Focal brain lesions from Acquired Brain Injuries (ABIs) present as regions of abnormal signal intensity on T1-weighted Magnetic Resonance Imaging (MRI) scans. These can disrupt automated neuroimaging processing algorithms traditionally developed on and for healthy brains. Lesion filling (or inpainting) can replace lesioned image voxels with signal intensities approximating healthy tissue. This cr…

In competing environments, both selective attention and audiovisual interaction can facilitate visual processing, yet whether their influences operate independently or interactively remains debated. Using electroencephalography (EEG), we addressed this issue by instructing participants to selectively attend to one of two lateralized flickering discs, which also changed their shapes either tempora…

Chronic bilateral vestibulopathy (BVP) occurs preferably in elderly patients presenting with postural imbalance and head movement induced oscillopsia. The condition is often incomplete with residual functions in both ears. Beyond the vestibular reflexive deficits, an impairment of spatial orientation and navigation has been described associated with an atrophy of the hippocampal formation. Howeve…

Chronic occupational manganese (Mn) overexposure is associated with motor and cognitive deficits, but its effects on hippocampal subfields remain underexplored. Although neurodegeneration is known to involve the hippocampus, subfield-specific structural abnormalities have received limited attention. This study aimed to assess the diagnostic power of hippocampal subfield volumes in discriminating …

Consistent with most findings from FXS patients and rodent models, our results demonstrated an increase in gamma power in fmr1KO female mice, reinforcing gamma power as a robust and reliable EEG phenotype across FXS models. Additionally, theta-gamma cross frequency amplitude coupling is inversely coupled in female FXS model, which is similar to what has been reported in FXS patients. Overall, our…