neurotoxicity

IntroductionEarly-life exposure to general anesthetics has been associated with increased neurodevelopmental vulnerability, but the cell type-resolved mechanisms remain incompletely understood. Here, we investigated whether isoflurane-induced neonatal neurotoxicity is associated with a glia-linked ferroptotic susceptibility state involving altered SLC7A11/GPX4 antioxidant defense signaling.Method…

Author: Prof. Robert Peter Biney & Dr. Thomas Amatey Tagoe Affiliations: Department of Pharmacotherapeutics and Pharmacy Practice, University of Cape Coast, Ghana; Department of Physiology, University of Ghana, Ghana Key themes: • Neuroscience development in Ghana • Early foundations in physiology and neurosurgery • Research on stress, neurotoxicity and disease • Capacity building and internation…

ObjectiveDioctyl terephthalate (DOTP), a widely used plasticizer in food packaging and environmental materials, has raised concerns regarding its potential impact on human health. This study aims to investigate the neurotoxicity-related mechanisms of DOTP through an integrated approach combining network toxicology, molecular dynamics simulations, and in vivo validation.MethodsWe retrieved the DOT…