IntroductionEarly-life exposure to general anesthetics has been associated with increased neurodevelopmental vulnerability, but the cell type-resolved mechanisms remain incompletely understood. Here, we investigated whether isoflurane-induced neonatal neurotoxicity is associated with a glia-linked ferroptotic susceptibility state involving altered SLC7A11/GPX4 antioxidant defense signaling.Method…
Author: Prof. Robert Peter Biney & Dr. Thomas Amatey Tagoe Affiliations: Department of Pharmacotherapeutics and Pharmacy Practice, University of Cape Coast, Ghana; Department of Physiology, University of Ghana, Ghana Key themes: • Neuroscience development in Ghana • Early foundations in physiology and neurosurgery • Research on stress, neurotoxicity and disease • Capacity building and internation…
ObjectiveDioctyl terephthalate (DOTP), a widely used plasticizer in food packaging and environmental materials, has raised concerns regarding its potential impact on human health. This study aims to investigate the neurotoxicity-related mechanisms of DOTP through an integrated approach combining network toxicology, molecular dynamics simulations, and in vivo validation.MethodsWe retrieved the DOT…
A new study published by Zhang et al. in ACS Nano reported on an experiment that exposed mice to both the magnetic fields emitted by Bluetooth earbuds and cell phones, as well as magnetite nanoparticles derived from air pollution. The researchers found that this combined exposure led to greater accumulation of nanoparticles in the brain and neurotoxic effects. To model real-world exposure, the re…
