[Proceedings of the National Academy of Sciences of the United States of America] Researchers developed a therapy based on autologous red blood cells as tolerizing carriers of autoantigens and tested these in an open-label, dose-escalation, Phase Ib clinical trial with clinical, imaging, and mechanistic readouts.
Nature Medicine, Published online: 09 July 2026; doi:10.1038/s41591-026-04490-8 The 2024 revision of the McDonald diagnostic criteria is an important step toward earlier and more inclusive diagnosis of multiple sclerosis. Realizing its full potential will require continued refinement of biomarkers, disease stratification and clinical trial approaches.
Higher-dose ocrelizumab produced greater peripheral B-cell depletion than the approved 600 mg regimen in two phase 3b trials of relapsing and primary progressive multiple sclerosis. However, the higher doses did not significantly delay disability progression, supporting the 600 mg dose as the current standard regimen with a favorable benefit-risk profile.
Two experimental drug molecules promoted myelin repair in MS disease models, pointing toward a possible future route for treating nerve damage rather than only suppressing inflammation. Multiple sclerosis (MS) is one of the leading causes of neurological disability in young adults, affecting nearly three million people worldwide. Despite decades of research and major advances in [...]
IntroductionThe aim of the study is to investigate the association between fatigue, cognitive impairment, and overall QoL in individuals with Multiple Sclerosis (MS).MethodsFifty-one patients with MS with a confirmed diagnosis of relapsing–remitting multiple sclerosis (RRMS), according to established diagnostic criteria were enrolled. Data were collected at a single time point to examine associat…
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Jessica Thomas was driving one day when she realized she was having problems with her vision. Over the next couple of weeks, she began experiencing some unexplained numbness, tingling, and cognitive issues. “I had trouble coming up with words, which was super frustrating, as I was in graduate school at the time,” says Jessica. Within a couple of months from the onset of that …
