Bipolar disorder (BD) is a severe and recurrent psychiatric disorder characterized by alternating manic, hypomanic, and depressive episodes, frequent comorbidity, high relapse rates, and an increased risk of suicide. Although the pathophysiology of BD remains incompletely understood, increasing evidence suggests that DNA methylation may represent an important epigenetic regulatory layer involved …
Lithium, the gold-standard treatment for bipolar disorder, exhibits highly heterogeneous clinical responses and no validated biological predictors of responsiveness are currently available. Emerging evidence suggests that the gut microbiota influences mood disorders and psychotropic drug response, raising the hypothesis that specific microbial signatures may modulate lithium responsiveness. In th…
A New Window into the Bipolar Brain Bipolar disorder (BD) affects more than 40 million people worldwide, yet its biological underpinnings remain incompletely understood. A new study led by researchers at UTHealth Houston and published in Epigenomics identifies distinctive microRNA... The post MicroRNA “Fingerprints” in the Blood May Offer Clues to Bipolar Disorder Biology appeared first on Louis …
Written by Joao L. de Quevedo, MD, PhD Introduction Electroconvulsive therapy (ECT) has been a subject of both fascination and controversy for decades. Often misunderstood due to its portrayal in popular media, ECT remains one of the most effective treatments for... The post Electroconvulsive Therapy (ECT) might be a Lifesaving Treatment Option for Bipolar Disorder. appeared first on Louis A. Fai…
