Journal of Molecular Medicine

Abstract The FDA’s approval of the Lumipulse G p-tau217/Aβ 1−42 plasma ratio enhances access to Alzheimer’s diagnostics but risks confusing convenience with biological accuracy. The assay is scalable and non-invasive, yet it relies on a ratio of two markers that are unstable and only partly specific to the disease, raising concerns about reproducibility and interpretation. The reported performanc…

Abstract Primary failure of eruption (PFE) is a rare autosomal disorder provoked by heterozygous mutations in the parathyroid hormone receptor 1 ( PTH1R ) gene. PTH1R is a G protein-coupled receptor (GPCR) which regulates intracellular signaling molecules like cAMP. By using CRISPR/Cas9, the pathogenic PTH1R variant, c.1050-3C>G, was introduced into the periodontal ligament (PDL-hTERT) cell li…

Non-alcoholic fatty liver disease and atherosclerosis may share a common pathogenesis involving chronic IL-1β-induced inflammation. We aimed to evaluate the efficacy of diacerein, an IL-1 pathway inhibitor, in improving liver fibrosis, steatosis, and atherosclerosis in apolipoprotein E-knockout (apoE k/o) mice. ApoE k/o mice fed a high-fat diet (HFD) were divided into three groups based on diacer…

Chronic kidney disease (CKD) is expected to be the fifth cause of global mortality by 2040. Modifiable and non-modifiable risk factors for CKD range from metabolic conditions, such as diabetes or obesity, to genetic defects. Regardless of the triggering factor, irreversible injury and loss of kidney cells result in the decline of kidney function. Renal damage often occurs through common signaling…