immune-cells-in-cancer

Nature Immunology, Published online: 15 June 2026; doi:10.1038/s41590-026-02568-6 Some patients with pyoderma gangrenosum harbor a mutation (R57C) in OTULIN that disrupts the interaction between OTULIN and LUBAC leading to hyperactivation in monocytes and enhanced susceptibility of keratinocytes to TNF-induced, caspase-dependent cell death. One patient treated with anti-TNF therapy showed clinica…

Nature Immunology, Published online: 15 June 2026; doi:10.1038/s41590-026-02563-x Here, the authors conduct integrated multiomics analysis of B cell activation, differentiation and diversification responses to malaria infection and provide a graphical user interface for readers to mine these data.

Nature Immunology, Published online: 15 June 2026; doi:10.1038/s41590-026-02569-5 This study compares the humoral response of individuals who received inactivated influenza vaccines to that of individuals who received an mRNA-based quadrivalent influenza vaccine. The mRNA-based vaccine induced prolonged germinal center responses, more antibodies and increased numbers of memory B cells.

Nature Communications, Published online: 15 June 2026; doi:10.1038/s41467-026-74420-2 Lampreys use variable lymphocyte receptors (VLRs) for adaptive immunity, but the cellular organization of VLR diversity is unknown. This study reveals an invariant VLR-like receptor in lamprey T-like cells that coordinates with diversified VLRC, defining a distinct T-like sub-population in lamprey.

Food-responsive enteropathy (FRE) is a common form of chronic inflammatory enteropathy in dogs. Its underlying molecular mechanisms remain incompletely characterized. Increasing evidence from human studies and emerging canine data suggests that bile acids (BAs) influence intestinal homeostasis and inflammation. Duodenal mucosal biopsies from dogs with FRE (n = 8) and healthy controls (n = 4) were…

Scientists studying the remarkable regenerative abilities of planarian flatworms have uncovered a previously unknown type of immune cell with an unusually destructive defense strategy. What if an immune cell could wipe out nearby threats by detonating itself? That is exactly what Stanford researchers have discovered in one of nature’s most unlikely creatures: the planarian flatworm. [...]

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-74318-z Mechanisms underlying effective immune escape in HPV-associated oropharyngeal cancers despite the presence of immune cells are incompletely understood. Here, authors use single-cell spatial analysis to show that tumors form distinct local immune niches, including hypoxic regions and chemokine foci, that shape im…

Scientists at Florida International University may have found a way to make a powerful cancer treatment work even better. The treatment, called CAR-T therapy, uses a patient’s own immune cells to fight cancer. Doctors remove special immune cells called T-cells from the body, genetically change them in a lab so they can recognize cancer, and […]

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-73931-2 Bone metastases derived from lung cancer typically exhibit an immunosuppressive microenvironment. This study identifies a YBX1 glycosylation–dependent mechanism that drives both metastasis and immunosuppression, and proposes the small molecule Icaritin as a potential therapeutic strategy through YBX1 degradation.

Metastasis remains the leading cause of death in breast cancer, yet the mechanisms that allow disseminated tumor cells to evade immune surveillance remain poorly understood. We found that NCOR2 promotes metastasis by suppressing antigen presentation and limiting tumor recognition by CD8 T cells.

The U.S. Food and Drug Administration (FDA) has approved pembrolizumab, an immunotherapy, plus belzutifan, a HIF-2α inhibitor, as adjuvant treatment for adult patients with renal cell carcinoma with a clear cell component (ccRCC) at intermediate-high or high risk of recurrence following nephrectomy, with or without resection of metastatic lesions.

The University of Oklahoma has received an $11.5 million award from the National Institutes of Health to establish the Oklahoma Center of ImmunoEngineering, a new research center designed to accelerate the study and treatment of diseases rooted in the immune system.

Nature Communications, Published online: 13 June 2026; doi:10.1038/s41467-026-74162-1 Alveolar macrophages can contribute to systemic anti-tumor responses. Here the authors describe a cascaded targeted liposomal nanomedicine for generating chimeric antigen receptor-modified alveolar macrophages via intrapulmonary nebulization, promoting anti-tumor immunity in lung cancer models.

Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by excessive secretion of parathyroid hormone (PTH).

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