Nature Communications, Published online: 15 June 2026; doi:10.1038/s41467-026-74420-2 Lampreys use variable lymphocyte receptors (VLRs) for adaptive immunity, but the cellular organization of VLR diversity is unknown. This study reveals an invariant VLR-like receptor in lamprey T-like cells that coordinates with diversified VLRC, defining a distinct T-like sub-population in lamprey.
An invariant VLR-like receptor refines the T-like cell framework in lamprey
Jialong Yang