physiology

Two-pore-domain K + channels (K2p), known previously as leak channels, are responsible for maintaining the resting membrane potential of cells. Fifteen subtypes are known to exist in humans and eleven are known in Drosophila melanogaster, as well as six subfamilies; however, little is known about the expression of these subtypes in various animal tissues or the impact of altered expression on cel…

Just a few minutes of very hard exercise may trigger surprisingly large changes throughout the body. New research from Rockefeller University found that short bursts of all-out sprinting changed hundreds of substances circulating in the blood almost immediately. The response was much larger than researchers saw after far longer sessions of moderate exercise. Six 30-second […] The post Three Minut…

BackgroundChronic ankle instability (CAI) is a common sequela of lateral ankle sprain and is associated with recurrent injury, persistent functional limitations, sensorimotor deficits, and impaired postural control. However, how individuals with CAI adapt to graded and combined sensory feedback disruption remains unclear. This study aimed to determine whether individuals with CAI exhibit altered …

Platelet-rich plasma (PRP) exhibits substantial inter-individual variability, yet the physiological factors influencing its composition remain poorly defined. Most studies evaluate PRP as a homogeneous product, potentially masking associations between donor-related characteristics and platelet parameters. This study aimed to determine how key physiological factors influence whole blood (WB) and P…

IntroductionObjective assessment of hindlimb skeletal muscles in dogs remains challenging in small animal practice. This study aimed to use computed tomography (CT) to characterize hindlimb muscle distribution, identify optimal measurement levels, and evaluate the clinical applicability of a palpation-based hindlimb muscle condition score (hMCS) system.MethodsThis prospective observational study …

IntroductionRespiration is increasingly recognized as a key modulator of brain-body interactions, influencing both neural and autonomic dynamics. While prior work has demonstrated respiratory-driven entrainment, it remains unclear whether distinct phases of the breathing cycle give rise to different dynamical regimes of cortical activity.MethodsIn this study, we investigated respiratory-phase-dep…

The heart’s developed pressure (DP) in Langendorff heart experiments increases with preload via the Frank-Starling mechanism up to a critical transition point at which DP starts to decrease with preload. A similar behavior is found at the cellular level, where the tension developed by skinned cardiac fibers or myocytes in isometric tension test increases with sarcomere length up to a transition p…

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