BMC Chemistry

Abstract Cytarabine (CYT) is a cornerstone in the treatment of acute myeloid leukemia (AML) and is often co-administered with granisetron (GRS) to manage chemotherapy-induced nausea and vomiting (CINV). A precise and sensitive thin-layer chromatographic (TLC) method was developed and validated for the simultaneous determination of CYT and GRS in spiked human plasma samples. Chromatographic separa…

Microrobotics technology shows great potential in the field of minimally invasive medicine but still faces key challenges regarding motion control, safety, and cost. Hence, a near-infrared light-response bilayer actuator is designed in this work. The light-driving mechanism and its application in the light-controlled drug release capsule system is deeply explored by taking the double-layer polyvi…

Abstract Stringent environmental regulations drive the quest for green corrosion inhibitors (greenish), with ionic liquids being prime candidates due to their high stability and low volatility and non-flammability. The present work investigates the synthesis, characterization, and corrosion inhibition performance of green ionic liquids based (ILs) on imidazole. The newly synthesized 1-acetyl-3-be…

Rupatadine (RUPA), a second-generation H₁-receptor antagonist, is used to treat allergies with a further antagonistic action on platelet-activating factor. Here, the binding interaction between RUPA and bovine serum albumin (BSA) has been investigated via various approaches, including spectrofluorimetric techniques, thermodynamic studies, Fourier transform infrared spectroscopy (FTIR),…

In this study, two new rhodanine derivative molecules (3 and 4) were synthesized, and the potentiometric sensor properties and certain biological functions of these novel molecules were investigated, following their characterization. The potentiometric performance characteristics of sensor 2 prepared using the molecule 3, and of sensor 10 prepared using the molecule 4 were further investigated un…

Revefenacin (REV) is an inhalation solution used for management of Chronic Obstructive Pulmonary Disease (COPD) in the USA, this is single medication that is an approved bronchodilator delivered by nebulization with a once-daily frequency. Even though the crucial necessity of quality control in pharmaceutical manufacturing, no officially recognized methods exist for REV determination in biologica…

In this study, the effect of nanoclay reinforcement on the mechanical and surface performance of glass/epoxy laminated composites was comprehensively investigated with the aim of jointly evaluating compression behavior and surface properties, which have been addressed only to a limited extent in the literature. In particular, the study aimed to reveal the role of the nanoclay ratio in the compres…

A simple, sensitive, precise, and cost-effective high-performance thin-layer chromatographic method has been developed and validated for the simultaneous determination of Amlodipine and some Angiotensin II Receptor Antagonist drugs, including Olmesartan, Telmisartan, Candesartan, Losartan, and Irbesartan, in spiked human plasma. The HPTLC analysis utilized a mobile phase consisting of toluene: et…

Owing to the widespread usage of synthetic dyes, water contamination prompted by these materials has led to a severe menace on aquatic ecosystem and also on living organisms health. Chitosan modified with cyanoguanidine (CCs), prepared in our previous study, was investigated herein for the first time to assess its adsorbing ability of Fast Green (FG) dye, to widen its applications. The free amino…

Niclosamide (NA) is widely used as an insecticide in agriculture and fisheries; however, its excessive application poses potential risks to food security and aquatic ecosystems. In this study, halloysite nanotubes (HNTs) were immobilized onto reduced graphene oxide (rGO) via a facile strategy to construct the HNTs-rGO nanocomposite. The introduction of HNTs effectively suppresses the interlayer b…

The increasing resistance of bacteria and cancer to present treatments is a clinical and laboratory concern. In this study, a novel Schiff base ligand (HL) was synthesized in this work through a solvent-free method, involving the reaction of 2,4-diamino-6-phenyl-1,3,5-triazine with 2-hydroxy-1-naphthaldehyde under mild and eco-friendly conditions. The Ni(II) and Zn(II) complexes were then synthes…

Water is vital to life, so preserving it from pollution is an important issue. Chromium, in its various oxidation states, poses a significant threat to water contamination. This study analyzes the sulfonation process, which improves the Cr (VI) adsorption capability of lignin (a bio-adsorbent generated from pine cones), to produce sulfonated lignin (SL). The optimal pH for Cr (VI) adsorption was …

Keratomycosis, a sight-threatening fungal infection of the cornea, can be more effectively treated with a novel combination of Natamycin (NAT, 5%) and Fluconazole (FLC, 0.2%) than with NAT alone. To support the development of this therapy, new sustainable, eco-friendly, and sensitive analytical methods were developed for the simultaneous quantification of both drugs in pharmaceutical formulations…

This is the first reported chromatographic method enabling simultaneous quantification of COL and DEX in pharmaceutical and plasma matrices together with a comprehensive, multi-tool sustainability assessment (including VIGI and EPPI). The method's short run time, high sensitivity, and favorable sustainability scores support its application in routine quality control and preclinical pharmacokineti…

Ethoniosomes have garnered significant interest as a novel class of lipid-based nano-carriers. Derived from the integration of ethanol and non-ionic surfactants within their vesicular structures, ethoniosomes exhibit superior physicochemical stability, enhanced skin permeability, and the capacity to encapsulate both hydrophilic and lipophilic drugs. In this study, three quick, easy, affordable, a…

This study evaluated the impact of different fertilizer treatments on the proximate composition and antioxidant properties of flour from two white-fleshed sweet potato varieties (PCS and LCCS). The tubers were cultivated in the Sayo district of the Kellem Wollega Zone, Ethiopia. A two-factor experimental design with three blocks was employed, incorporating six treatments: eluate (T1), digestate (…

Marine microalgae rich in high-quality proteins are highly favored in the development of bioactive peptides. However, the scarcity of effective preparation methods still limits its application in healthy improvement. This study aimed to search for the effective natural antioxidative peptides from the microalga Porphyridium cruentum (P. cruentum) for protection skin cells against chronic oxidative…

Dental caries is a disease of tooth tissue that can lead to complications, with Enterococcus faecalis being one of the Gram-positive bacteria that plays a crucial role in the infection process. Red betel leaves (Piper crocatum Ruiz & Pav.) are known to contain various phytochemicals; however, the antibacterial potential of Crocatin A, one of its isolated compounds, against E. faecalis and its mol…