Antioxidant dipeptide Threonyltyrosine from Porphyridium cruentum: in silico prediction and in vitro protection against paraquat-induced HaCaT cell damage

Marine microalgae rich in high-quality proteins are highly favored in the development of bioactive peptides. However, the scarcity of effective preparation methods still limits its application in healthy improvement. This study aimed to search for the effective natural antioxidative peptides from the microalga Porphyridium cruentum (P. cruentum) for protection skin cells against chronic oxidative stress by UPLC-Q-Exactive MS identification coupled to in silico prospection. An antioxidative dipep