Cell Communication and Signaling

Abstract Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is associated with a poorer prognosis compared to its HPV-positive counterpart; however, the underlying regulatory molecular mechanisms driving its progression remain poorly understood. In this study, we identify BTB Domain and CNC Homolog 1 (BACH1) as a critical oncogenic regulator that is upregulated in H…

Abstract Background Checkpoint kinase 2 (CHEK2) is a tumor suppressor that safeguards genome integrity in the nucleus. It is also localized at the mother centriole. But the role of CHEK2 in this structure remains unclear. The primary cilium acts as a sensory organelle that regulates various aspects of cell behavior. However, the connection between CHEK2 and primary cilia has not been elucidated. …

Abstract Background Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have transformed non-small cell lung cancer (NSCLC) treatment, offering substantial survival benefits. However, acquired resistance remains a significant obstacle, undermining long-term efficacy. While specific mechanisms of EGFR-TKI resistance have been reported, potential shared mechanisms across EGFR-TK…

Recent studies have revealed that accumulation of cellular nitric oxide (NO) resulting from protein disulfide isomerase (PDI)-catalyzed dimerization (i.e., catalytic activation) of nitric oxide synthase (NOS) is a pivotal upstream event in the induction of ferroptosis. l-Buthionine-(S,R)-sulfoximine (BSO), an inhibitor of the γ-glutamylcysteine synthase, can induce cellular glutathione depletion …

Gastrointestinal stromal tumors (GIST) are mainly caused by gain-of-function mutations in KIT or PDGFRA genes and constitute the most common malignant neoplasm of mesenchymal origin. Dysregulation of the Hippo pathway and its downstream effectors YAP1 and TAZ has been implicated in GIST progression, yet their individual contributions remain unclear. Given emerging evidence of non‑redundant YAP1/T…

Mechanobiology has played significant roles in guiding and regulating cellular activities, such as morphogenesis, organogenesis, wound healing. Inter-/intracellular force or stiffness as an engine induced cell to reshape their morphologies leading to distinct cell functionalization. Therefore, biophysical changes (roughness, stiffness) of cell membrane are highly correlated to the varies in cell …

Apoptosis is a prevalent feature of the tumor microenvironment, driven not only by the rapid cellular turnover of high-grade cancers but also by chemotherapeutic agents. Although accumulating apoptotic cells can paradoxically support cancer cell survival and contribute to tumor recurrence, the roles of apoptotic cells in triple-negative breast cancer (TNBC) have not been elucidated. TYRO3, a rece…

The CXCL12/CXCR4/ACKR3 axis is essential for brain development and homeostasis. Dysregulation of CXCL12 or its receptors has been associated with various CNS disorders related to neurodevelopmental defects, neuroinflammation, neurodegeneration and brain tumors. This signaling axis represents an attractive therapeutic target, and large efforts have led to the development and use of specific pharma…

Dynamic gene expression in response to lifestyle and environmental changes is a hallmark of diabetic pathophysiology. Although altered DNA methylation is implicated during diabetes, upstream regulatory events remain poorly understood. Expression and activity of H19, DNMTs, Hk2, and Eno3 were evaluated in diabetic db/db mouse models and Hepa 1–6, HepG2 cells using qRT-PCR, Western blotting and enz…

Environmental constant light exposure could induce biological rhythm disruption, which negatively induces metabolic syndrome, mood disorders, cognitive declines, chronic disease risk, and reproduction defects. Previous studies indicated that constant light exposure affected ovary function and oocyte quality. Here, we reported that melatonin supplementation effectively alleviated the adverse effec…