Mechanism of l-Buthionine-(S,R)-sulfoximine-induced ferroptotic cell death in mouse hippocampal neuronal cells

Recent studies have revealed that accumulation of cellular nitric oxide (NO) resulting from protein disulfide isomerase (PDI)-catalyzed dimerization (i.e., catalytic activation) of nitric oxide synthase (NOS) is a pivotal upstream event in the induction of ferroptosis. l-Buthionine-(S,R)-sulfoximine (BSO), an inhibitor of the γ-glutamylcysteine synthase, can induce cellular glutathione depletion and ferroptosis. The present study aims to investigate whether PDI-centered signaling axis also media