Different contributions of YAP1 and TAZ in the regulation of GIST tumorigenic properties
Irène Pezzati·Prisca Boisguérin·Clémentine Ayélé Teko-Agbo·Karidia Konate·Mathieu Béranger·Éric Vivès·Frédéric Chibon·Sandrine Faure·Pascal de Santa Barbara·César Serrano·Sébastien Deshayes·Thania Hammoum
Gastrointestinal stromal tumors (GIST) are mainly caused by gain-of-function mutations in KIT or PDGFRA genes and constitute the most common malignant neoplasm of mesenchymal origin. Dysregulation of the Hippo pathway and its downstream effectors YAP1 and TAZ has been implicated in GIST progression, yet their individual contributions remain unclear. Given emerging evidence of non‑redundant YAP1/TAZ functions in cancer, we sought to dissect their respective roles in GIST tumorigenic properties. W