A positive feedback loop between BACH1 and IL-1β promotes the progression of HPV-negative head and neck squamous cell carcinoma
Zishanbai Zhang·Lin Shan·Wenjuan Wang·Minghui Zhao·Yiming Ding·Tingyao Ma·Zhaohan Zhang·Xilin Wang·Yuchen Xiang·Yaning Wang·WenYing ZHONG·Zicheng Wu·Yiran Meng·Xiaohong Chen·Miao Wang
Abstract Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is associated with a poorer prognosis compared to its HPV-positive counterpart; however, the underlying regulatory molecular mechanisms driving its progression remain poorly understood. In this study, we identify BTB Domain and CNC Homolog 1 (BACH1) as a critical oncogenic regulator that is upregulated in HPV-negative HNSCC. We demonstrate that BACH1 promotes tumor progression by enhancing the proliferatio