Targeting TYRO3 attenuates apoptotic cell–driven cancer stemness in triple negative breast cancer
Phương Thảo Trần·Keon Wook Kang·Won-Cheol Jeong·Jaewoo Park·Myung Jun Kim·Sarang Oh·Yong June Choi·Munkyung Choi·Miso Park·Wan Seob Shim
Apoptosis is a prevalent feature of the tumor microenvironment, driven not only by the rapid cellular turnover of high-grade cancers but also by chemotherapeutic agents. Although accumulating apoptotic cells can paradoxically support cancer cell survival and contribute to tumor recurrence, the roles of apoptotic cells in triple-negative breast cancer (TNBC) have not been elucidated. TYRO3, a receptor tyrosine kinase frequently overexpressed in cancers, plays a pivotal role in malignant progressi