Vaccine & Immunotherapy Center

Join the Vaccine and Immunotherapy Center for the Annual Professor Dulcie V. Coleman Lecture with Dr. Peter Hotez – expert in global health and vaccine advocate, as he discusses “Global Vaccines and Immunizations: in a time of antiscience, antivaccination, climate change and megacities.” More details can be found below.   https://partners.zoom.us/j/82851400783 The post Annual Dulcie V. Coleman Le…

The summer students had a wonderful visit to the British Consulate in Boston, meeting with the Science and Technology team there and discussing ongoing research work at the VIC lab. Thank you, Sarah, Mary and Ona at the Consulate for the warm welcome and an enjoyable discussion over tea, coffee and cake.   Pictured – third […] The post Visit to the British Consulate with VIC Summer Students appea…

In the United States, cancer is the second leading cause of death. One promising therapy is in the development of cancer vaccines which have thus far been hindered by a lack of efficacy. This is largely because cancers develop an immunosuppressive environment which dampens our immune systems ability to respond effectively to infection. This article […] The post Publication from the Gemechu lab – …

I recently returned from the international SPIE Photonics West Conference in San Francisco, having had two papers accepted for presentation and manuscripts published. It was an incredible opportunity for me that was a direct result from my summer at the Vaccine and Immunotherapy Center (VIC), Harvard Medical School, and the Wellman Centre for Photomedicine at Massachusetts General […] The post Al…

This Fall, Saumya Maheshwari and James Aspden jointly won the prestigious Arthur Fonville Award, presented yearly for a stroke research dissertation by a medical student in Edinburgh or Amsterdam. The two scientists received this distinction for research conducted at VIC, in the laboratory of Dr. Ruxandra Sîrbulescu, focusing on the use of B cells as […] The post Saumya Maheshwari and James Aspde…

Dr. Poznansky discusses research at VIC investigating B cells as a potential cell therapy for treating neural injury. Research in the VIC lab demonstrates B cells to be both neuroprotective and neuroregenerative in the context of intracranial hemorrhage in a murine mouse model.https://youtu.be/0cWLyByNX-g?si=Q7LsPV3Y3fiN9k8b The post Dr. Mark Poznansky speaks on B cell therapy in the context of r…

In new research published in The FASEB Journal, Dr. Sîrbulescu’s lab demonstrated the remarkable protective effect of B cells in the context of ALS in a murine model and observed decreased inflammation in a patient with the disease. Previous work by the group showed that the direct application of purified B cells, which are immune […] The post Allogeneic B cell immunomodulatory therapy in amyotro…

The Reeves lab recently published a study in eJHaem exploring the immune system in patients with myeloproliferative neoplasms (MPNs), a type of rare blood cancer. These patients are particularly vulnerable to infections and often require immunosuppressive drugs, highlighting the importance of effective vaccination. Our study found that MPN patients exhibit significant changes in immune cells, […]…

Our team at VIC recently published a review article in the Trends in Molecular Medicine Journal, under the guidance of Dr. Gemechu. Clinical trial data increasingly show that targeted immunotherapies such as antibodies, T-cells and vaccines improve outcomes when delivered in combination with the immunomodulatory drug (IMiD) derivatives lenalidomide or pomalidomide. We review these clinical […] Th…

Our team at VIC recently published an opinion article published in Trends in Immunology Journal under the guidance of Dr. Gemechu. Immunotherapies have revolutionized treatment outcomes for cancer, but many cancers are resistant to such therapies. Cancers have an altered environment compared to healthy tissue, and part of this is due to changes in the […] The post Targeting metabolic pathways to …