IntroductionSeasonal variation can influence plant metabolite composition and modify antimicrobial performance; however, the relationship between seasonal metabolomic changes and antibacterial activity remains poorly understood in many arid-land medicinal plants. To our knowledge, this is the first study to integrate GC–MS metabolomics, antibacterial screening, and phage–extract interaction testi…
BackgroundThe rising burden of antimicrobial resistance (AMR) necessitates new bioactive molecules that are both sustainable and therapeutically relevant. Endophytic actinomycetes, particularly Streptomyces, represent a valuable but underexplored source of secondary metabolites with pharmaceutical potential.MethodsAn endophytic strain, Streptomyces sp. VITGV100, was isolated from tomato stems and…
This paper describes the development of a platform technology for a new class of antimicrobial biologicals called AbTids to target drug resistant bacteria using pathogen specific camelid antibodies and antimicrobial peptide conjugates.
