Genome mining strategies to unlock the metabolic potential of Streptomyces sp. VITGV100 (MCC 4961) for next-generation antimicrobial discovery
John Godwin Christopher
BackgroundThe rising burden of antimicrobial resistance (AMR) necessitates new bioactive molecules that are both sustainable and therapeutically relevant. Endophytic actinomycetes, particularly Streptomyces, represent a valuable but underexplored source of secondary metabolites with pharmaceutical potential.MethodsAn endophytic strain, Streptomyces sp. VITGV100, was isolated from tomato stems and subjected to genome sequencing and antiSMASH analysis. A total of 35 compounds were predicted and th