World Journal of Gastroenterology

BACKGROUND Dendrobium officinale (D. officinale ) is a traditional Chinese herb that has been studied extensively for its medicinal properties, including gastrointestinal protection, anti-aging effects, and antioxidant properties. However, the molecular mechanisms by which D. officinale delays aging have not been fully elucidated. AIM To investigate the effects of D. officinale extract (DOE) on e…

BACKGROUND Even with stent patency following transjugular intrahepatic portosystemic shunt (TIPS) placement, some patients still experience recurrent variceal bleeding. AIM To identify risk factors and develop a predictive model for rebleeding in patients with patent TIPS stents. METHODS Cirrhotic patients (n = 647) undergoing TIPS (2010-2024) were retrospectively analyzed and grouped by rebleedi…

BACKGROUND Endoscopic retrograde cholangiopancreatography (ERCP) is a pivotal diagnostic and therapeutic modality for the assessment and management of pancreatic and bile duct disorders. Percutaneous transhepatic biliary drainage (PTBD) is a prevalent and progressively favored primary treatment modality for malignant obstructive jaundice, providing rapid biliary decompression, achieving high tech…

We read with interest the study by Wang et al entitled “Interpretable machine learning model for early complication prediction after split liver transplantation”. Split liver transplantation (SLT) expands the donor pool but is associated with an increased risk of early postoperative complications (EPCs) due to extended resection surfaces and altered partial graft hemodynamics. This study aimed to…

BACKGROUND Previous studies have not clarified a universally acknowledged treatment approach that can eradicate small bowel hemangiomas while minimizing harm to patients. Although studies have indicated that endoscopic interventions have promising treatment effects with minimal invasiveness, no comparison of different types of endoscopic therapies has been conducted. AIM To compare the clinical e…

BACKGROUND Contrast-enhanced ultrasound (CEUS) performed intraoperatively for colorectal cancer liver metastases can detect concealed liver metastases not identified during preoperative examinations or routine intraoperative ultrasound. This capability is critical for determining the appropriate surgical approach. AIM To explore the advantages of Sonazoid-CEUS (S-CEUS) over gray-scale ultrasound …

This Expression of Concern is issued in regards to the article by Ladas et al , titled “Colonic gas explosion during therapeutic colonoscopy with electrocautery”, published in the World Journal of Gastroenterology (WJG ) in 2007 (https://dx.doi.org/10.3748/wjg.v13.i40.5295 ). Concerns have been raised about whether the article’s recommendation to avoid bowel preparation agents containing poorly a…

The highest incidence rates of gallbladder cancer (GBC) are registered among the populations of South America (Bolivia: 7.6 per 100000 population), Asia (Bangladesh: 5.25 per 100000), and North Africa (Algeria: 2.65 per 100000). Recent studies demonstrate a significant association between GBC, cholelithiasis and extrahepatic gastrointestinal cancer, which allows for the development of a systemic …

BACKGROUND Postoperative recurrence is the main cause of treatment failure in borderline resectable pancreatic cancer (BRPC) patients. Elaborating patterns and risk factors for tumor recurrence can help clinicians tailor treatment decision, thereby improving the clinical outcome of these patients. However, although upfront surgery serves as an important treatment option for BRPC patients and can …

Immunoglobulin G4 (IgG4)-related disease is a systemic fibro-inflammatory condition characterized by tumefactive lesions, dense lymphoplasmacytic infiltration, and storiform fibrosis. Among its various presentations, IgG4-related digestive system disorders (IgG4-DSD) are the most prevalent, frequently mimicking malignancies and posing significant diagnostic challenges. This review synthesizes adv…

BACKGROUND Beta-1 receptor blockade is well characterized for its protective effects against septic symptoms, and esmolol (ES) is a selective β1-adrenoceptor antagonist. AIM To assess the effects of ES on lipopolysaccharide (LPS)-induced septic intestinal damage and explore the associated mechanism by focusing on the AMPK/mTOR/ULK1 pathway. METHODS Sepsis was induced via an intraperitoneal inject…

BACKGROUND Laparoscopy-assisted radical gastrectomy is a well-established treatment for gastric cancer. However, its safety and feasibility in patients with a history of upper abdominal surgery (UAS) remain controversial. AIM To evaluate perioperative outcomes and oncologic radicality in gastric cancer patients with prior UAS undergoing laparoscopic gastrectomy, using a novel adhesion-risk strati…

BACKGROUND There are still large variations in survival among patients with hepatocellular carcinoma (HCC) who received preoperative radiotherapy (RT), necessitating early recurrence (ER) risk stratification for decision-making and more appropriate management of patients. AIM To develop prognostic models integrating magnetic resonance imaging features and clinico-therapeutic-pathological variable…

BACKGROUND Gastric cancer (GC) poses significant treatment challenges due to late-stage diagnosis and the limited efficacy of conventional therapies. Immunotherapy, particularly immune checkpoint inhibitors such as pembrolizumab and nivolumab targeting the programmed death-ligand 1 (PD-L1) pathway, has shown promising results. Pembrolizumab is effective in PD-L1-positive tumors, while nivolumab i…

Inflammation-based indices such as the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, and nutritional metrics like the prognostic nutritional index or controlling nutritional status, offer pragmatic risk stratification in hepatocellular carcinoma treated with lenvatinib, these scores being not immutable. Nutrition and physical activity can influe…

BACKGROUND Tropomyosin 3 (TPM3) has been implicated in the progression of several cancers; however, its specific role and underlying molecular mechanisms in gastric cancer (GC) remain unclear. The current research aimed to investigate the role of TPM3 in the onset and advancement of GC, along with the related molecular pathways. AIM To investigate TPM3’s role in enhancing GC malignancy and elucid…

Inflammatory bowel disease (IBD), which includes Crohn’s disease and ulcerative colitis, is a group of chronic relapsing disorders caused by dysregulated mucosal immunity, altered gut microbiota, and impaired epithelial barrier function. There is increasing evidence linking circadian disruptions, such as shift work, jet lag, sleep loss, light misalignment, and irregular eating patterns, to the ri…

BACKGROUND Myeloid sarcoma is a rare extramedullary tumor of immature myeloid cells, often associated with acute myeloid leukemia. Primary intestinal myeloid sarcoma without hematologic disease is uncommon and can mimic gastrointestinal stromal tumor (GIST). CASE SUMMARY A 52-year-old man presented with upper abdominal pain, distension, and nausea. Computed tomography revealed a small intestinal …

BACKGROUND Irritable bowel syndrome (IBS) is a common disorder of gut-brain interaction and is characterized by chronic abdominal pain and altered bowel habits. Current evidence indicates that immune activation and autoantibody production contribute to IBS pathogenesis. However, the mechanisms by which autoantibodies affect the enteric nervous system and contribute to IBS-related symptoms are poo…

Split liver transplantation (SLT) has always existed in a delicate tension between expanding access and accepting complexity. By converting one deceased donor liver into two grafts, SLT directly addresses the persistent organ shortage, but at the cost of extended transection planes, altered hemodynamics, and a consistently higher rate of early postoperative complications (EPC) compared with whole…