Beyond the score: Diet and exercise as modifiers of inflammation-based prognosis in lenvatinib-treated hepatocellular carcinoma

Inflammation-based indices such as the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, systemic immune-inflammation index, and nutritional metrics like the prognostic nutritional index or controlling nutritional status, offer pragmatic risk stratification in hepatocellular carcinoma treated with lenvatinib, these scores being not immutable. Nutrition and physical activity can influence the pathways they capture: Systemic inflammation, immune competence, and skeletal-muscle status.