Nature Communications, Published online: 16 June 2026; doi:10.1038/s41467-026-74057-1 Fam K. et al. identified peptidoglycan hydrolase SagA that modulates antibiotic susceptibility of vancomycin-resistant Enterococcus faecium. Pharmacological inhibition of SagA restored vancomycin efficacy across multidrug-resistant clinical strains.