Emergence and spread of Plasmodium falciparum PX1 polymorphisms associated with decreased susceptibility to antimalarials in Uganda

Nature Medicine, Published online: 17 August 2026; doi:10.1038/s41591-026-04590-5 Whole-genome sequencing of clinical isolates of Plasmodium falciparum in Uganda reveals rapid selection of a PX1-associated haplotype linked to reduced susceptibility to commonly used antimalarials.