AimsAstrocytes provide crucial metabolic support for neurons and undergo significant metabolic changes in Alzheimer’s disease (AD). Aldolase C (ALDOC), an astrocyte-enriched glycolytic enzyme, may play a role in this process. This study aimed to investigate whether ALDOC modulates astrocytic metabolism to support neuronal energy supply in patients with AD and to assess its therapeutic potential.MethodsHippocampal and cortical tissues from 6-month-old APP/PS1 and wild-type mice were subjected to