ZNF274 constrains lineage plasticity and drives intrinsic resistance to CDK7 inhibitors in pancreatic cancer
Sita Kugel
Nature Communications, Published online: 23 May 2026; doi:10.1038/s41467-026-73380-x Pancreatic ductal adenocarcinoma (PDAC) classical and basal subtypes can interconvert. Here, the authors discover that ZNF274 loss drives a classical to basal transition in PDAC via suppression of ZEB1 and HERV-driven interferon signaling, increasing the sensitivity to CDK7 inhibition.