α/Sulfonyl-γ-AApeptide foldamers mitigate Alzheimer’s disease pathology by stabilizing transient helical domains in Aβ
Jianfeng Cai
Nature Communications, Published online: 12 May 2026; doi:10.1038/s41467-026-73075-3 Foldamer M4 inhibits Aβ42 aggregation, disrupts existing assemblies, and restores neuronal function. This foldamer reduces oxidative stress, improves mitochondrial integrity, and alleviates pathology and cognitive decline in an Alzheimer’s disease mouse model.