alzheimers-disease

Using a National Institutes of Health grant, the team hopes to identify critical changes in the progression of Alzheimer’s that could lead to earlier, more effective treatments. The post USC researchers to build a new model of neurodegeneration in Alzheimer’s disease appeared first on USC .

White matter (WM) has traditionally been considered structurally important but functionally inert in fMRI research. However, growing evidence indicates that WM exhibits meaningful BOLD fluctuations and participates in functional connectivity. Here, we investigate alterations in WM functional network connectivity (FNC) across the Alzheimer’s disease (AD) spectrum using resting-state fMRI data from…

Research from UC Santa Cruz indicates that the P3 peptide—an alternative cleavage product of the amyloid precursor protein—may play a role in Alzheimer’s disease. For many years, pharmaceutical companies have focused their Alzheimer’s drug development efforts on amyloid beta, a peptide known for forming sticky deposits in the brain. Billions of dollars and decades of [...]

A new study from researchers highlights an unexpected player in Alzheimer’s disease: aging astrocytes. Senescent astrocytes have been identified as a major contributor to Alzheimer’s progression. The cells lose protective functions and fuel inflammation, particularly in APOE4 carriers. The findings highlight senolytic drugs as a potential new therapy. For the first time, the research team [...]

A new class of Alzheimer’s drugs has been shown to slow the condition’s progression by removing clumps of protein known as amyloid plaques from the brain. However, few countries have approved use of the medications as they bring only modest improvements, are expensive and can have serious side effects. Discover more about these controversial drugs and how they have changed our understanding of Al…

After decades of building and revitalizing numerous multimillion-dollar restaurant chains, entrepreneur Ron Shaich is embracing one more challenge: leaving a positive impact on the world. “I’ve had the good fortune to have some success in life,” he says. “I want to make sure I do a good job stewarding the blessings I’ve had and use […]

To better understand the complex genetic and molecular underpinnings of AD in both its sporadic and genetic forms, researchers from the UC Irvine Charlie Dunlop School of Biological Sciences and the UC Irvine School of Medicine conducted groundbreaking research recently published in Nature Genetics.

Brain Awareness Month: An Overview of Alzheimer's Disease Jul 1, 2023 10 min read An Overview of Alzheimer's Disease Authors: Somil Bhushan, Ayush Halder Editor: Raayan Dhar This article was written with the purpose of educating and raising awareness for Alzheimer's Disease for the month of June (Brain Awareness Month) Introduction Alzheimer’s disease is a neurodegenerative disease that primarily…

Li Gan studies how abnormal proteins and the body’s immune system drive Alzheimer’s disease. Read the full story here.

A collaboration between Weill Cornell Medicine scientists and other leaders in Alzheimer’s disease research has revealed widespread metabolic changes in the brains of individuals with Alzheimer’s disease. The findings could lead to the development of new treatments aimed at ameliorating the metabolic effects of the disease. For the study, published July 13 in Alzheimer’s and Dementia, the investi…

Alzheimer’s disease is the most common form of dementia, in which people become forgetful and confused, usually starting in older age. People with Alzheimer’s have a build-up of two kinds of protein clumps in the brain: amyloid and tau. These seem to start forming in our memory centres, two small curved structures on either side of the head called the hippocampi, before spreading all over the bra…

The post Mark Brody, M.D. and Stephen Thein, PhD, Named to Cortexyme’s Clinical Advisory Board to Support the Company’s Alzheimer’s Clinical Development Program appeared first on ERG Clinical .

Alzheimer’s disease (AD) is a progressive, fatal disorder without cure. The mechanism(s) of the disease is not entirely understood, impeding development of effective therapy. Current treatments provide short-term alleviation of some symptoms, but generally […]

Alzheimer’s disease (AD), the most common type of dementia is a progressive neurodegenerative disorder characterized by a decline in cognitive function and memory impairment. Characteristic neuropathological features of AD are accumulation of amyloid […]