Nature Communications, Published online: 19 June 2026; doi:10.1038/s41467-026-74490-2 ISG15 regulates antiviral immune responses through protein modification. Here, the authors identify USP24 as a deISGylase that controls MOV10 ISGylation and IFN-β production, revealing a mechanism that fine-tunes innate immunity.
USP24 is a cross-reactive DUB targeting MOV10 to regulate IFN-I production
Aysegul Sapmaz