Frontiers in Neuroscience | Neurodegeneration section | New and Recent Articles

Variation in the microtubule-binding protein tau is causally implicated in numerous neurodegenerative diseases, including Alzheimer’s disease. However, the mechanisms by which such variation results in disease are not well understood. The JNPL3(P301L) mouse model mimics the effects of the P301L mutation on human tau associated with frontotemporal dementia. As previously reported, phospho-tau aggr…

IntroductionWhile gene set enrichment analysis (GSEA) framework is widely used on transcriptomics or proteomics data, its applications beyond “omics” data has not been extensively explored. Its principal nature enables it to apply to any dataset where variables can be rationally sorted into categories, or sets. This study demonstrates a novel application of GSEA outside of its traditional use by …

Intracranial hemorrhage is a devastating neurological condition associated with high mortality and limited therapeutic options beyond surgical management. Increasing evidence identifies iron released from hemoglobin degradation as a central mediator of secondary brain injury and a critical trigger for chronic neurodegenerative processes that persist long after the acute hemorrhagic event across h…

BackgroundPrion diseases are rare, transmissible, and invariably fatal neurodegenerative disorders caused by the conformational conversion of cellular prion protein (PrPC) into its pathogenic isoform (PrPSc). Despite decades of research, no licensed disease-modifying therapies are currently available. This reflects the rapid clinical course of these disorders, the difficulty of early diagnosis, a…

Metabolic dysfunction-Associated Steatotic liver disease (MASLD) is one of the most common systemic diseases causing chronic liver diseases. Current evidence indicates that cognitive-related deficits occur frequently in MASLD, causing significant impacts on patients and their families, and even possibly increasing the economic and psychological burdens on healthcare, productivity, and nursing sta…

ObjectiveThis study aimed to investigate the association between deep medullary veins (DMVs) score and comorbid idiopathic normal pressure hydrocephalus (iNPH) in patients with arteriolosclerotic cerebral small vessel disease (aCSVD), and to analyze its role as an independent associated factor.MethodsA total of 80 patients with aCSVD, 40 patients with arteriolosclerotic cerebral small vessel dise…

Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide classically implicated in the regulation of energy homeostasis, sleep–wake cycle and motivated behaviors. Over the last 30 years, an increasing amount of evidence has revealed a complex, non-linear role in memory processing. In this mini-review, we summarize experimental findings on the multifaceted influence of MCH on memory, hig…

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by debilitating motor impairment, cognitive decline, and a substantial reduction in patient quality of life. While pharmacological treatments and standard physiotherapy provide essential symptomatic relief, they often offer only transient benefits. Consequently, there is growing interest in non-pharmacological inte…

The development of Alzheimer disease (AD) involves a cluster of pathogenic processes, including amyloid-beta (Aβ) deposition, tau-mediated neurodegeneration, chronic neuroinflammation, oxidative stress (OS), metabolic dysregulation, and disruption of circadian rhythms. Nuclear hormone receptor, Retinoic Acid-Related Orphan Receptor Alpha (RORα) was shown to regulate multiple neuroprotective pathw…