Orchestrated and dynamic nucleotide addition cycle during respiratory syncytial virus early-stage elongation
Bo Liang
Nature Communications, Published online: 29 April 2026; doi:10.1038/s41467-026-72519-0 The cryo-EM study of RSV polymerase during early-stage RNA elongation reveals four key nucleotide addition states, providing the first comprehensive insights into orchestrated macrodomain rearrangements and micro-motif changes that drive catalysis.