Using the TRUPATH platform to analyse GPCR | BMG LABTECH

The G protein-coupled receptor (GPCR) family is comprised of hundreds of receptors that respond to a variety of stimuli to modulate cellular activity. Their ubiquitous expression and cell membrane localization make them attractive. In fact, GPCR represents the most highly targeted protein family by FDA-approved drugs. Biased agonism, the concept whereby ligands select for and stabilise receptor states that preferentially interact with certain effectors, could be used to enhance therapeutic...