Application and translational research of magnesium in nursing care of orthopedic diseases: from mechanism to clinical translation
Yaojing Ma
Magnesium is an essential bioactive ion that plays a central role in skeletal physiology. However, its contributions to bone biology and orthopedic practice are only beginning. Beyond its structural incorporation into bone mineral, magnesium dynamically regulates osteoblast and osteoclast function through signaling networks, including PI3K/Akt, TRPM, and the OPG/RANKL/RANK axis. Disruption of magnesium homeostasis has been increasingly implicated in osteoporosis, delayed fracture healing, and ot