BackgroundComplex febrile seizures (CFS) confer an elevated risk of epilepsy progression; however, the underlying genetic architecture remains insufficiently characterized in Chinese pediatric populations. This study aimed to delineate the mutational landscape and genotype–phenotype associations in a clinically stratified high-risk febrile seizure cohort.MethodsThis retrospective, single-center study enrolled 233 children (aged 6 months–6 years) who were consecutively screened at the Wuhan Child