Soluble bacterial lipopeptides suppress gasdermin D-associated IL-33 release in keratinocytes and atopic dermatitis in mice
Joanne L. Pennock
Nature Communications, Published online: 13 May 2026; doi:10.1038/s41467-026-72376-x Here, the authors show that bacteria release immunosuppressive lipopeptides that suppress eczema and may serve as a potential therapy. This activity is independent of toll-like receptor signalling but involves gasdermin D-induced release of IL-33.