Nature Communications, Published online: 04 June 2026; doi:10.1038/s41467-026-73806-6 MET upregulation drives many human cancers. Herein, the authors identify a G-quadruplex in the MET promoter that recruits LRPPRC to boost MET transcription, and show that nitidine acts as a molecular glue to stabilize the LRPPRC–MET-G4 complex, suppressing MET expression and inhibiting tumor growth.