Electrophilic compound screening identifies GPX4-dependent ferroptosis as a senescence vulnerability
Jesús Gil
Nature Cell Biology, Published online: 24 April 2026; doi:10.1038/s41556-026-01921-z D’Ambrosio et al. screen 10,480 electrophilic compounds for senolytic effects and show that senolytic chloroacetamides or GPX4 inhibitors selectively kill senescent cells by ferroptosis.